Hafif Bilişsel Bozukluğu Olan Bireylerde Aerobik Egzersiz: Geleneksel Derleme
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DOI:
https://doi.org/10.5281/zenodo.10329138Anahtar Kelimeler:
Aerobik egzersiz, hafif bilişsel bozukluk, risk fakörleri, terapatik egzersizÖzet
Aerobik egzersiz, demansın öncüsü olan Hafif Bilişsel Bozukluk (HBB) için potansiyel bir terapötik müdahale olarak ortaya çıkmıştır. Aerobik egzersizin terapötik faydaları hem klinik hem de moleküler alanları içerecek şekilde çok yönlüdür. Klinik olarak aerobik egzersizin, HBB riskini önemli ölçüde artıran hipertansiyon ve tip 2 diabetes mellitus gibi durumları azalttığı gösterilmiştir. Ayrıca, nitrik oksit salınımını uyararak arteriyel esnekliği artırır ve kan basıncını düşürür. Moleküler düzeyde, aerobik egzersizin sırasıyla beyin iltihabı ve nörogenez için çok önemli hücreler olan mikroglia ve astrositlerin aktivasyonunu modüle ettiği varsayılmaktadır. Ayrıca aerobik egzersizin sinaptik plastisite ve nöroproteksiyonu artırabilecek irisin, katepsin B, CLU ve GPLD1 gibi egzersiz faktörlerinin salınımını teşvik ettiği öne sürülmüştür. Sonuç olarak, düzenli aerobik egzersiz yaşlı bireylerde HBB gelişme riskini potansiyel olarak önleyebilir veya azaltabilir.
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