Aerobic Exercise in Individuals with Mild Cognitive Impairment: A Narrative Review


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Authors

DOI:

https://doi.org/10.5281/zenodo.10329138

Keywords:

Aerobic exercise, exercise therapy, mild cognitive impairment, risk factors

Abstract

Aerobic exercise has been proposed as a potential therapeutic intervention for mild cognitive impairment (MCI), a precursor of dementia. The benefits of aerobic exercise therapy are many and include both clinical and molecular domains. Clinical trials have demonstrated the efficacy of aerobic exercise in reducing factors known to significantly increase the risk of HBB, including hypertension and type 2 diabetes. Aerobic exercise promotes arterial elasticity and lowers blood pressure by stimulating the release of nitric oxide. At the molecular level, aerobic exercise is thought to modulate the activation of microglia and astrocytes, cells that are critical for brain inflammation and neurogenesis, respectively. It has also been suggested that aerobic exercise promotes the release of exercise factors such as irisin, cathepsin B, CLU, and GPLD1, which may enhance synaptic plasticity and neuroprotection. In conclusion, regular aerobic exercise may prevent or reduce the risk of developing HBB in the elderly.

References

Alpsoy, Ş. (2020). Exercise and hypertension. Physical Exercise for Human Health, 153-167.

Association, A. s. (2010). Alzheimer's disease facts and figures. Alzheimer's & dementia, 6(2), 158-194.

Bahureksa, L., Najafi, B., Saleh, A., Sabbagh, M., Coon, D., Mohler, M. J., & Schwenk, M. (2016). The impact of mild cognitive impairment on gait and balance: a systematic review and meta-analysis of studies using instrumented assessment. Gerontology, 63(1), 67-83.

Baker, L. D., Frank, L. L., Foster-Schubert, K., Green, P. S., Wilkinson, C. W., McTiernan, A., Plymate, S. R., Fishel, M. A., Watson, G. S., & Cholerton, B. A. (2010). Effects of aerobic exercise on mild cognitive impairment: a controlled trial. Archives of neurology, 67(1), 71-79.

Braz de Oliveira, M. P., Moreira Padovez, R. d. F. C., Serrão, P. R. M. d. S., Gomes dos Santos, J., Silva, D. C. P. d., & Andrade, L. P. d. (2023). Is physical exercise effective at improving body structure & function and activity outcomes in individuals with Mild Cognitive Impairment? a systematic review with quality of evidence assessment. Disability and rehabilitation, 45(4), 575-587.

Caldas, É. C., Rezende, L. A., Oliveira, K. d. S., Pinheiro, H. A., Melo, G. F. d., & Vilaça, K. H. C. (2017). Muscle strength, lower extremity functional performance and body composition in elderly women with mild cognitive impairment. Fisioterapia em Movimento, 30, 753-759.

Chen, F.-T., Etnier, J. L., Chan, K.-H., Chiu, P.-K., Hung, T.-M., & Chang, Y.-K. (2020). Effects of exercise training interventions on executive function in older adults: a systematic review and meta-analysis. Sports medicine, 50(8), 1451-1467.

Chen, K., Wang, K., & Wang, T. (2022). Protective effect of irisin against Alzheimer’s disease. Frontiers in psychiatry, 13, 967683.

de Senna, P. N., Xavier, L. L., Bagatini, P. B., Saur, L., Galland, F., Zanotto, C., Bernardi, C., Nardin, P., Gonçalves, C. A., & Achaval, M. (2015). Physical training improves non-spatial memory, locomotor skills and the blood brain barrier in diabetic rats. Brain research, 1618, 75-82.

Demurtas, J., Schoene, D., Torbahn, G., Marengoni, A., Grande, G., Zou, L., Petrovic, M., Maggi, S., Cesari, M., & Lamb, S. (2020). Physical activity and exercise in mild cognitive impairment and dementia: an umbrella review of intervention and observational studies. Journal of the American Medical Directors Association, 21(10), 1415-1422. e1416.

Freeman, M. R. (2010). Specification and morphogenesis of astrocytes. Science, 330(6005), 774-778.

Haeger, A., Costa, A. S., Schulz, J. B., & Reetz, K. (2019). Cerebral changes improved by physical activity during cognitive decline: a systematic review on MRI studies. NeuroImage: Clinical, 23, 101933.

He, X.-f., Liu, D.-x., Zhang, Q., Liang, F.-y., Dai, G.-y., Zeng, J.-s., Pei, Z., Xu, G.-q., & Lan, Y. (2017). Voluntary exercise promotes glymphatic clearance of amyloid beta and reduces the activation of astrocytes and microglia in aged mice. Frontiers in molecular neuroscience, 10, 144.

Horowitz, A. M., Fan, X., Bieri, G., Smith, L. K., Sanchez-Diaz, C. I., Schroer, A. B., Gontier, G., Casaletto, K. B., Kramer, J. H., & Williams, K. E. (2020). Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain. Science, 369(6500), 167-173.

Huang, B., Chen, K., & Li, Y. (2023). Aerobic exercise, an effective prevention and treatment for mild cognitive impairment. Frontiers in Aging Neuroscience, 15.

Jia, L., Du, Y., Chu, L., Zhang, Z., Li, F., Lyu, D., Li, Y., Zhu, M., Jiao, H., & Song, Y. (2020). Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study. The Lancet public health, 5(12), e661-e671.

Jongsiriyanyong, S., & Limpawattana, P. (2018). Mild cognitive impairment in clinical practice: a review article. American Journal of Alzheimer's Disease & Other Dementias®, 33(8), 500-507.

Kalaria, R. N., Maestre, G. E., Arizaga, R., Friedland, R. P., Galasko, D., Hall, K., Luchsinger, J. A., Ogunniyi, A., Perry, E. K., & Potocnik, F. (2008). Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors. The Lancet Neurology, 7(9), 812-826.

Karasar, N. (2005). Bilimsel araştırma yöntemi. 15. Baskı. Nobel Yayın Dağıtım, Ankara.

Law, C.-K., Lam, F. M., Chung, R. C., & Pang, M. Y. (2020). Physical exercise attenuates cognitive decline and reduces behavioural problems in people with mild cognitive impairment and dementia: a systematic review. Journal of physiotherapy, 66(1), 9-18.

Li, H., Su, W., Dang, H., Han, K., Lu, H., Yue, S., & Zhang, H. (2022). Exercise Training for Mild Cognitive Impairment Adults Older Than 60: A Systematic Review and Meta-Analysis. Journal of Alzheimer's Disease(Preprint), 1-16.

Liu-Ambrose, T., Nagamatsu, L. S., Graf, P., Beattie, B. L., Ashe, M. C., & Handy, T. C. (2010). Resistance training and executive functions: a 12-month randomized controlled trial. Archives of internal medicine, 170(2), 170-178.

Lu, Y., Bu, F.-Q., Wang, F., Liu, L., Zhang, S., Wang, G., & Hu, X.-Y. (2023). Recent advances on the molecular mechanisms of exercise-induced improvements of cognitive dysfunction. Translational Neurodegeneration, 12(1), 9.

Maass, A., Düzel, S., Brigadski, T., Goerke, M., Becke, A., Sobieray, U., Neumann, K., Lövdén, M., Lindenberger, U., & Bäckman, L. (2016). Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults. Neuroimage, 131, 142-154.

Marinus, N., Hansen, D., Feys, P., Meesen, R., Timmermans, A., & Spildooren, J. (2019). The impact of different types of exercise training on peripheral blood brain-derived neurotrophic factor concentrations in older adults: a meta-analysis. Sports medicine, 49, 1529-1546.

Mee-Inta, O., Zhao, Z.-W., & Kuo, Y.-M. (2019). Physical exercise inhibits inflammation and microglial activation. Cells, 8(7), 691.

Merom, D., Grunseit, A., Eramudugolla, R., Jefferis, B., Mcneill, J., & Anstey, K. J. (2016). Cognitive benefits of social dancing and walking in old age: the dancing mind randomized controlled trial. Frontiers in Aging Neuroscience, 26.

Nelson, A. P., & O'Connor, M. G. (2008). Mild cognitive impairment: a neuropsychological perspective. CNS spectrums, 13(1), 56-64.

Organization, W. H. (2013). Oral health surveys: basic methods. World Health Organization.

Overton, M., Pihlsgård, M., & Elmståhl, S. (2019). Prevalence and incidence of mild cognitive impairment across subtypes, age, and sex. Dementia and Geriatric Cognitive Disorders, 47(4-6), 219-232.

Pang, R., Wang, X., Pei, F., Zhang, W., Shen, J., Gao, X., & Chang, C. (2019). Regular exercise enhances cognitive function and intracephalic GLUT expression in Alzheimer’s disease model mice. Journal of Alzheimer's Disease, 72(1), 83-96.

Pedersen, M. M., Holt, N. E., Grande, L., Kurlinski, L. A., Beauchamp, M. K., Kiely, D. K., Petersen, J., Leveille, S., & Bean, J. F. (2014). Mild cognitive impairment status and mobility performance: an analysis from the Boston RISE study. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 69(12), 1511-1518.

Petersen, R. C., Lopez, O., Armstrong, M. J., Getchius, T. S., Ganguli, M., Gloss, D., Gronseth, G. S., Marson, D., Pringsheim, T., & Day, G. S. (2018). Practice guideline update summary: Mild cognitive impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology, 90(3), 126-135.

Rodakowski, J., Saghafi, E., Butters, M. A., & Skidmore, E. R. (2015). Non-pharmacological interventions for adults with mild cognitive impairment and early stage dementia: An updated scoping review. Molecular aspects of medicine, 43, 38-53.

Saco‐Ledo, G., Valenzuela, P. L., Ruiz‐Hurtado, G., Ruilope, L. M., & Lucia, A. (2020). Exercise reduces ambulatory blood pressure in patients with hypertension: a systematic review and meta‐analysis of randomized controlled trials. Journal of the American Heart Association, 9(24), e018487.

Townsend, L. K., MacPherson, R. E., & Wright, D. C. (2021). New horizon: exercise and a focus on tissue-brain crosstalk. The Journal of Clinical Endocrinology & Metabolism, 106(8), 2147-2163.

Wortmann, M. (2012). Dementia: a global health priority-highlights from an ADI and World Health Organization report. Alzheimer's research & therapy, 4, 1-3.

Published

2023-12-18

How to Cite

DİKMEN HOŞBAŞ, B., KARAMANCIOĞLU, B., & DEMİRCİ, D. (2023). Aerobic Exercise in Individuals with Mild Cognitive Impairment: A Narrative Review. International Journal of Holistic Health, Sports and Recreation, 2(2), 59–66. https://doi.org/10.5281/zenodo.10329138