Investigation Of NO, İL-6, and TNF- Levels In Mothers And Infants Diagnosed With Intrauterine Growth Restriction (IUGR)
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https://doi.org/10.5281/zenodo.12600499Keywords:
Pregnancy, IUGG, nitric oxide, IL-6, TNF-αAbstract
Intrauterine growth restriction (IUGR) is characterized by the retardation of fetal growth and development due to factors such as inadequate nutrition or oxygen intake during pregnancy. This condition can lead to various health problems after birth. This study was conducted to investigate the levels of nitric oxide (NO), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) in mothers and infant pairs diagnosed with IUGR. The study included 12 mother-infant pairs diagnosed with IUGR and 90 healthy mother-infant pairs. NO, IL-6, and TNF-α levels in maternal blood and infant cord blood were compared between these groups. Measurements revealed that NO levels in maternal blood and infant cord blood in the IUGR group were significantly lower compared to the control group. However, no significant difference was found in IL-6 levels in maternal blood between the IUGR and control groups. Nevertheless, IL-6 levels in cord blood of infants diagnosed with IUGR were significantly lower compared to the control group. Although TNF-α levels were measured higher in maternal blood, they were not statistically significant. In the IUGR group, cord blood TNF-α levels were found to be high and statistically significant. These findings suggest the potential role of NO, IL-6, and TNF-α in understanding the pathophysiology of IUGR. In conclusion, attributing significant increases and decreases in parameters studied in maternal and infant blood to a single cause of IUGR is not feasible, given the involvement of various factors. More homogeneous study groups could lead to more specific results and enable detailed interpretations.
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